Detailed Information
Cited 1 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Hepatoprotective effects of ginseng intestinal metabolite IH-901 on chemical-induced hepatic damage
- Authors
- Sohn, UD; Ko, SK; Choi, TS; Im, BO; Han, ST; Yang, BW; Sung, JH; Kim, YS; Woo, JG; Cho, YR; Min, YS; Jeong, JH; Lee, BY
- Issue Date
- Aug-2005
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- hepatoprotective effects; white ginseng; intestinal metabolite; IH-901
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.14, no.4, pp 558 - 560
- Pages
- 3
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 14
- Number
- 4
- Start Page
- 558
- End Page
- 560
- ISSN
- 1226-7708
2092-6456
- Abstract
- Hepatoprotective effects of white ginseng extract (WGE), and IH-901 (20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol) derived from intestinal metabolite of ginsenoside Rb, were studied using two experimental animal models with chemical-induced hepatic damage. Administration of WGE (200 and 500 mg/kg) and IH-901 (0.01, 0.05, and 0.1 mM/ kg) significantly decreased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in acute hepatitic mice induced by CCl4. Administration of WGE (100 mg/kg) and IH-901 (0.02, 0.04, and 0.08 mM/kg) significantly decreased AST and ALT levels in acute hepatitic rats induced by D-galactosamine. AST and ALT levels of IH-901 groups decreased. These results suggested WGE and IH-901 may have protective effects against chemical-induced hepatic damage.
- Files in This Item
- There are no files associated with this item.
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.