Immunohistochemical study on the distribution of phosphorylated extracellular signal-regulated kinase (ERK) in the central nervous system of SOD1(G93A) transgenic mice
- Authors
- Chung, YH; Joo, KM; Lim, HC; Cho, MH; Kim, D; Lee, WB; Cha, CI
- Issue Date
- Jul-2005
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- amyotrophic lateral sclerosis (ALS); extracellular signal-regulated kinases (ERK); SOD1(G93A) mutant transgenic mice; astrocyte
- Citation
- BRAIN RESEARCH, v.1050, no.1-2, pp 203 - 209
- Pages
- 7
- Journal Title
- BRAIN RESEARCH
- Volume
- 1050
- Number
- 1-2
- Start Page
- 203
- End Page
- 209
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24564
- DOI
- 10.1016/j.brainres.2005.05.060
- ISSN
- 0006-8993
1872-6240
- Abstract
- In the present study, we performed immunohistochemical studies to investigate the changes of phosphorylated extracellular signal-regulated kinases (PERK) in the central nervous system of SOD1(G93A) transgenic mice. In symptomatic transgenic mice, pERK-immunoreactive astrocytes were detected in the spinal cord, brainstem, central gray and cerebellar nuclei. In contrast to symptomatic mice, no pERK-immunoreactive astrocytes were observed in any brain region of wtSOD1 and presymptomatic mice, and the number and intensity of stained neurons were not different at the age of 8 weeks and 13 weeks. Interestingly, region-specific alterations in pERK immunoreactivity were observed in the hippocampal region and cerebellum. These results provide the first evidence that pERK-immunoreactive astrocytes were found in the CNS of SOD1(G93A) transgenic mice after clinical symptoms, showing a possible consequence of the pathological process of ALS. This study has also demonstrated that pERK increases in the hippocampus and cerebellum, suggesting a role of pERK in an abnormality of cognitive and/or motor function in ALS, respectively. However, the mechanisms underlying the increased immunoreactivity for pERK and the functional implications require elucidation. (C) 2005 Elsevier B.V All rights reserved.
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