The activation of ERK1/2 via a tyrosine kinase pathway attenuates trail- induced apoptosis in HeLa cells
- Authors
- Lee, Myoung Woo; Bach, Jae Hyung; Lee, Hyun Jung; Lee, Do Yeon; Joo, Wan Seok; Kim, Yong Sik; Park, Soon Cheol; Kim, Kyung Yong; Lee, Won Bok; Kim, Sung Su
- Issue Date
- 2005
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- TRAIL; ERK1/2; tyrosine kinase; Bcl-2 protein; apoptosis
- Citation
- CANCER INVESTIGATION, v.23, no.7, pp 586 - 592
- Pages
- 7
- Journal Title
- CANCER INVESTIGATION
- Volume
- 23
- Number
- 7
- Start Page
- 586
- End Page
- 592
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24700
- DOI
- 10.1080/07357900500283036
- ISSN
- 0735-7907
1532-4192
- Abstract
- Tumor necrosis factor-related apoptosis-inducing ligand ( TRAIL) serves as an extracellular signal that triggers apoptosis in tumor cells. To characterize the molecular events involved in TRAIL-induced apoptotic signaling, we investigated the role of extracellular signal-regulated kinase 1/2 (ERK1/2) in HeLa cell death. Here we show that TRAIL-activated ERK1/2 through a tyrosine kinase-dependent pathway, subsequently elevated antiapoptotic Bcl-2 protein levels. ERK1/2 inhibition with PD98059 promoted apoptotic cell death through the downregulation of ERK1/2 activity and Bcl-2 protein levels. Moreover, tyrosine kinase inhibition with Genistein in TRAIL-induced apoptosis effectively attenuated ERK1/2 activity and enhanced apoptotic cell death. Taken together, our results indicate that ERK1/2 activation via tyrosine kinase pathway plays a protective role as the cellular defense mechanism through the upregulation of Bcl-2 protein levels in TRAIL-induced apoptosis.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
- College of Medicine > College of Medicine > 1. Journal Articles
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