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Fluorinated quinoid inhibitor: possible 'pure' arylator predicted by the simple theoretical calculation
- Issue Date
- Aug-2004
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Cdc25 inhibitor; quinones; reduction potential
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.14, no.15, pp 4103 - 4105
- Pages
- 3
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 14
- Number
- 15
- Start Page
- 4103
- End Page
- 4105
- ISSN
- 0960-894X
1464-3405
- Abstract
- We report on the fluorinated form of Cpd 5 as a cell growth inhibitor. This compound is 3-fold more potent than the parent Cpd 5 and is predicted, using the semi-empirical AM1 method to be only an arylator of cysteine-containing proteins, without generating reactive oxygen species. (C) 2004 Elsevier Ltd. All rights reserved.
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