Detailed Information
Cited 71 time in 
Cited 92 time in 
Cited 92 time in
Metadata Downloads
A new caffeoyl quinic acid from Aster scaber and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase
- Authors
- Kwon, Hak Cheol; Jung, Chil Mann; Shin, Cha Gyun; Lee, Jong Kyo; Choi, Sang Un; Kim, Sun Yeou; Lee, Kang Ro
- Issue Date
- Nov-2000
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- Aster scaber; Asteraceae; caffeoyl quinic acid; (-) 3.5-dicaffeoyl-muco-quinic acid; HIV-1 integrase
- Citation
- CHEMICAL & PHARMACEUTICAL BULLETIN, v.48, no.11, pp 1796 - 1798
- Pages
- 3
- Journal Title
- CHEMICAL & PHARMACEUTICAL BULLETIN
- Volume
- 48
- Number
- 11
- Start Page
- 1796
- End Page
- 1798
- ISSN
- 0009-2363
1347-5223
- Abstract
- The phytochemical study of the aerial parts of Aster scaber THUNB. (Asteraceae) yielded a new caffeoyl quinic acid, (-) 3,5-dicaffeoyl-muco-quinic acid (2) and three known compounds, (-) 3,5-dicaffeoyl quinic acid (1), (-) 4,5-dicaffeoyl quinic acid (3), (-) 5-caffeoyl quinic acid (4). The structures were established by high resolution spectroscopic methods. The antiviral effects against HIV-1 integrase of the compounds was evaluated. (-) 3,5-Dicaffeoyl-muco-quinic acid (2) exhibited potent antiviral activity with an IC50 value of 7.0 +/- 1.3 mug/ml.
- Files in This Item
- There are no files associated with this item.
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.