Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Synthesis of 6-exomethylenepenams as beta-lactamase inhibitors
- Issue Date
- Feb-1999
- Publisher
- PHARMACEUTICAL SOCIETY KOREA
- Keywords
- triazole; 6-exomethylenepenam; beta-lactamase inhibitors
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.22, no.1, pp 68 - 71
- Pages
- 4
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 22
- Number
- 1
- Start Page
- 68
- End Page
- 71
- ISSN
- 0253-6269
- Abstract
- The 6,6-dibromopenam (6) was treated with CH3MgBr and carbaldehyde 5 to afford the hydroxy compound 7, which was reacted with acetic anhydride to give acetoxy compound 8. The deacetobromination of 8 with zinc and acetic acid gave 6-exomethylenepenams, E-isomer 10 and Z-isomer 9, which was oxidized to sulfone 11 by m-CPBA. The p-methoxybenzyl compounds were deprotected by AlCl3 and neutralized to give the sodium salts 12, 13 and 14.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.