Reaction-based fluorometric analysis of: N -bromosuccinimide by oxidative deprotection of dithiane
- Authors
- Lee, Yu Jeong; Choi, Myung Gil; Park, Tae Jung; Chang, Suk-Kyu
- Issue Date
- May-2019
- Publisher
- Royal Society of Chemistry
- Citation
- Analyst, v.144, no.10, pp 3267 - 3273
- Pages
- 7
- Journal Title
- Analyst
- Volume
- 144
- Number
- 10
- Start Page
- 3267
- End Page
- 3273
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/26368
- DOI
- 10.1039/c8an02125b
- ISSN
- 0003-2654
1364-5528
- Abstract
- In this study, a fluorescent probe is developed for the first time for N-bromosuccinimide (NBS), a synthetically and analytically important compound. Pyrene-dithiane-based probe 1 showed prominently selective and sensitive signaling behavior toward NBS owing to the oxidative cleavage of the dithiane protecting group of 1-pyrenecarboxaldehyde. The NBS-selective signaling of the probe was possible under competitive conditions in the presence of common metal ions and anions as a background. The detection limit of the probe for NBS was found to be 5.6 × 10 -8 M (10.0 ppb). The signaling product was sufficiently stable under the oxidative stress of NBS in contrast to another tested compound, 6-methoxy-2-naphthaldehyde-based dithiane derivative 2, which showed a gradually decaying response because of the reaction of the signaling product with the residual NBS. In the practical application of the probe, a smartphone was used as a stand-alone device, and the fluorometric assays of the commercial NBS reagents could be conducted rapidly and in a convenient manner. © 2019 The Royal Society of Chemistry.
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