Anti-pancreatic-cancer effect of a newly bred cabbage line, Amtak-ssamchae, is mediated by a reduction in regulatory-T-cell recruitment
- Authors
- Kim, S.; Kim, S.; Jo, E.-S.; Gil, K.; Kim, N.-Y.; Park, J.S.; Park, D.; Park, S.-Y.; Hwang, K.W.
- Issue Date
- Jul-2019
- Publisher
- Elsevier Ltd
- Keywords
- Amtak-ssamchae; Chemokine receptor; Chemokine receptor ligand; Pancreatic cancer; Regulatory T cell; β-carotene
- Citation
- Journal of Functional Foods, v.58, pp 301 - 310
- Pages
- 10
- Journal Title
- Journal of Functional Foods
- Volume
- 58
- Start Page
- 301
- End Page
- 310
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/26375
- DOI
- 10.1016/j.jff.2019.05.006
- ISSN
- 1756-4646
2214-9414
- Abstract
- We aimed to investigate possible anticancer effects of Amtak-ssamchae (a newly bred cabbage line containing more carotenoids) in an in vitro pancreatic-tumor cell model and an in vivo model (Panc02 cells). In an in vitro assay, Amtak-ssamchae significantly reduced the viability of Panc02 cells relative to normal ssamchae. Furthermore, an Amtak-ssamchae extract significantly reduced the tumor size in mice inoculated with Panc02 cells, and this effect was accompanied by changes in the cell population in/near the tumor and spleen. Treatment with the extract of the new cabbage line blocked regulatory-T-cell recruitment, which is known as the main pathological mechanism of action of pancreatic cancer to avoid host immunity. Additionally, Amtak-ssamchae (not the normal line) contained β-carotene (at 27.9 ± 2.1 μg/g). Thus, we suggest that the Amtak-ssamchae extract could be a resource for natural supplements and functional foods for combating pancreatic cancer. © 2019 Elsevier Ltd
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