대장직장암에서 Survivin과 HSP90 단백발현과 예후인자와의 관계Expression of Survivin and HSP90 in Colorectal Cancer and its Relationship with Clinicopathologic Factors
- Authors
- 김택현; 이태진; 김범규; 차성재; 박성준; 임현묵; 박성일
- Issue Date
- Feb-2006
- Publisher
- 대한외과학회
- Keywords
- Survivin; HSP90; Colorectal cancer; 대장직장암
- Citation
- 대한외과학회지, v.70, no.2, pp 113 - 119
- Pages
- 7
- Journal Title
- 대한외과학회지
- Volume
- 70
- Number
- 2
- Start Page
- 113
- End Page
- 119
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/29258
- ISSN
- 2288-6575
2288--679
- Abstract
- Purpose: Survivin is an inhibitor of apoptosis protein and it is overexpressed in most human cancers. Recent data demonstrated that survivin-HSP90 complex regulate apoptosis. We assessed expression of survivin and HSP90 by using immunohistochemistry with colorectal cancer tissue and correlate it with clinicopathologic prognostic parameters. Methods: Using immunohistochemistry, survivin and HSP90 expression were evaluated on paraffin sections of fifty-six colorectal carcinomas. Various clinicopathologic parameters including histologic differentiation grade, T-stage, nodal metastasis, stage were obtained from pathologic records. Results: Survivin expression were observed in 30 cases (53.6%). The expression of survivin showed no statistically significant correlation with histologic differentiation grade, T-stage, nodal metastasis, stage. HSP90 expression were observed in 31 cases (55.4%). The expression of HSP90 showed a statistically significant correlation with histologic differentiation grade (P=0.035) and stage (P=0.017). There were a significant correlation between survivin expression and HSP90 expression (P=0.018).
Conclusion: Survivin and HSP90 was expressed in colorectal cancer. The expression of HSP90 correlates with histologic differentiation grade, stage. The above results suggest that HSP90 could be a prognostic marker of poor outcome in colorectal carcinoma. (J Korean Surg Soc 2006;70: 113-119)
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