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2-치환 플라본 유도체의 합성Synthesis of 2-Substituted Flavone Derivatives
- Issue Date
- 2006
- Publisher
- 대한약학회
- Keywords
- flavone; tyrosinase inhibitors
- Citation
- 약 학 회 지, v.50, no.6, pp 398 - 402
- Pages
- 5
- Journal Title
- 약 학 회 지
- Volume
- 50
- Number
- 6
- Start Page
- 398
- End Page
- 402
- ISSN
- 0377-9556
- Abstract
- Flavone was found to inhibit tyrosinase and reduce synthesis of melanin to show skin-lightening effect. Withthe hope of identifying skin-lightening flavones, we synthesized flavone analogs. Substituted benzoic acids (1) were treatedwith oxalyl chloride in DMF to yield benzoyl chlorides (2), which were reacted with 2-hydroxyacetophenones (3) to aford2-benzoyloxyacetophenones (4). These acetophenones (4) were converted into 1,3-diketones (5) with base and then treatedwith acid to give flavone derivatives (6).Keywords .
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