대장 직장암에서 D2-40을 이용한 림프계 미세 혈관 밀도와 혈관 내피세포 성장 인자-C의 단백 발현의 의미The Significance of the Lymphatic Micro Vessel Density and Vascular Endothelial Growth Factor- C Expression for Colorectal Cancer
- Authors
- 김태희; 김용석; 최영철; 김범규; 이태진; 박용검
- Issue Date
- Nov-2007
- Publisher
- 대한외과학회
- Keywords
- Colorectral cancer; VEGF-C; D2-40; Lymphatic microvessel density; 대장 직장암; 미세혈관밀도
- Citation
- 대한외과학회지, v.73, no.5, pp 406 - 411
- Pages
- 6
- Journal Title
- 대한외과학회지
- Volume
- 73
- Number
- 5
- Start Page
- 406
- End Page
- 411
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/30488
- ISSN
- 2288-6575
2288--679
- Abstract
- Purpose: Studying the prognostic factors of distant metastasis is quite important for predicting these patients’ prognosis and also for providing standards for post-operative adjuvant chemotherapy. Microbiological studies currently enable researchers to look for new predictors of distant metastasis in patients with colon cancers. In this study, the VEGF-C expression and stain rate of D2-40 were investigated as prognostic factors.
Methods: 79 Specimens were collected from the patients who underwent colorectal operation and they were pathologicaly diagnosed with cancer at Chung-Ang University hospital from March, 2003 to Sept. 2005. The specimens were immunohistochemically stained to detect the VEGF-c expression and the D2- 40 stain rate.
Results: The VEGF-C expression was related to lymph node metastasis, tumor embolism and the frequency of the T- stage, but it was not related to progression of cancer. The D2-40 stained lymphatic density was significantly increased in the cases with lymph node metastasis and in the tumor embolism cases; furthermore, the density became higher in relation to the increased T-stage and progression of cancer.
Conclusion: The VEGF-C expression and lymphatic vessel density appear to be prognostic factors for colon cancer. (J Korean Surg Soc 2007;73:406-411)
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