대장암에서 CD31과 D2-40 발현에 의한 혈관성 및 림프관성 미세혈관 밀도 측정Angiogenic and Lymphangiogenic Microvessel Density in Terms of the Expression of CD31 and D2-40 in Colon Cancer
- Authors
- 윤상인; 김범규; 차성재; 박성준; 장인택; 박성일; 이태진
- Issue Date
- Oct-2007
- Publisher
- 대한외과학회
- Keywords
- 대장암; 혈관신생; 림프관 신생; Colon cancer; CD31; D2-40; Angiogenesis; Lymphangiogenesis
- Citation
- 대한외과학회지, v.73, no.4, pp 315 - 320
- Pages
- 6
- Journal Title
- 대한외과학회지
- Volume
- 73
- Number
- 4
- Start Page
- 315
- End Page
- 320
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/30515
- ISSN
- 2288-6575
2288--679
- Abstract
- Purpose: Angiogenesis and lymphangiogenesis play important roles in the growth, progression and metastasis of colon cancer. We performed this study in order to investigate the significance of the CD31 and D2-40 expressions as prognostic factors in colon cancer.
Methods: The angiogenic and lymphagiogenic microvessel density was assessed by immunohistochemical staining of CD31 and D2-40 on samples that were resected from 66 patients with colorectal cancer.
Results: Strong correlation was observed between the CD31 microvessel density and being positive for having tumor emboli and lymph node metastasis (P=0.001, P=0.003). The D2-40 lymphatic vessel density was correlated with being positive for having tumor emboli (P=0.0001), the depth of invasion (P=0.0001), lymph node metastasis (P= 0.0001) and the cancer stage (P=0.0001). The D2-40 lymphatic vessel density was also correlated with the CD31 count (P=0.003).
Conclusion: These results suggested that the CD31 and D2-40 expressions are useful predictors of lymph node metastasis and they are prognostic factors for colon cancer. (J Korean Surg Soc 2007;73:315-320)
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