Anomalous Dynamics of in Vivo Cargo Delivery by Motor Protein Multiplexes
- Authors
- Shin, Kyujin; Song, Sanggeun; Song, Yo Han; Hahn, Seungsoo; Kim, Ji-Hyun; Lee, Gibok; Jeong, In-Chun; Sung, Jaeyoung; Lee, Kang Taek
- Issue Date
- Jun-2019
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF PHYSICAL CHEMISTRY LETTERS, v.10, no.11, pp 3071 - 3079
- Pages
- 9
- Journal Title
- JOURNAL OF PHYSICAL CHEMISTRY LETTERS
- Volume
- 10
- Number
- 11
- Start Page
- 3071
- End Page
- 3079
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/32726
- DOI
- 10.1021/acs.jpclett.9b01106
- ISSN
- 1948-7185
- Abstract
- Vesicle transport conducted by motor protein multiplexes (MPMs), which is ubiquitous among eukaryotes, shows anomalous and stochastic dynamics qualitatively different from the dynamics of thermal motion and artificial active matter; the relationship between in vivo vesicle-delivery dynamics and the underlying physicochemical processes is not yet quantitatively understood. Addressing this issue, we perform accurate tracking of individual vesicles, containing upconverting nanoparticles, transported by kinesin-dynein-multiplexes along axonal microtubules. The mean-square-displacement of vesicles along the microtubule exhibits unusual dynamic phase transitions that are seemingly inconsistent with the scaling behavior of the meanfirst-passage time over the travel length. These paradoxical results and the vesicle displacement distribution are quantitatively explained and predicted by a multimode MPM model, developed in the current work, where ATP-hydrolysis-coupled motion of MPM has both unidirectional and bidirectional modes.
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Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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