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Estrogenic Xenobiotics가 돼지 정자의 운동성 및 운동역학에 미치는 영향Effect of Estrogenic Xonibiotics on Boar Sperm Motility and Motion Kinematics

Authors
오신애박유진송원희El-Sayed A. Mohamed방명걸
Issue Date
2011
Publisher
한국동물번식학회
Keywords
Boar spermatozoa; Endocrine disruptors; Xenobiotics; Motility; Motion kinematics
Citation
Reproductive & Developmental biology, v.35, no.1, pp 47 - 54
Pages
8
Journal Title
Reproductive & Developmental biology
Volume
35
Number
1
Start Page
47
End Page
54
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/35040
ISSN
1738-2432
Abstract
Endocrine disruptors bind to hormone receptors on sperm membrane, therefore spermatozoa are potentially a useful model for examining estrogenic activities of endocrine disruptors. The objective of this study was to compare the effects of two xenoestrogenic compounds [genistein (Gen) and 4-tert-octylphenol (OP)] to those of two steroids [estrogen (E2) and progesterone (P4)] on boar sperm % motility and motion kinematics of in vitro. Porcine spermatozoa were incubated with various concentrations (0.001~100 μM) of each chemical for 15 or 30 min, and then assessed % motility and sperm motion kinematics using computer assisted sperm analyzer (CASA). Each chemical decreased sperm % motility, and OP decreased VSL and VAP compared with untreated control(p<0.05). E2 stimulated the motion kinematic changes except VCL. Moreover, Gen had effects on VCL and VAP alterations after 30 min incubation. In summary, since all chemicals studied effectively altered sperm % motility and motion kinematics, it was concluded that porcine spermatozoa could be a useful model for in vitro screening of potential endocrine disruptors.
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