Estrogenic Xenobiotics가 돼지 정자의 운동성 및 운동역학에 미치는 영향Effect of Estrogenic Xonibiotics on Boar Sperm Motility and Motion Kinematics
- Authors
- 오신애; 박유진; 송원희; El-Sayed A. Mohamed; 방명걸
- Issue Date
- 2011
- Publisher
- 한국동물번식학회
- Keywords
- Boar spermatozoa; Endocrine disruptors; Xenobiotics; Motility; Motion kinematics
- Citation
- Reproductive & Developmental biology, v.35, no.1, pp 47 - 54
- Pages
- 8
- Journal Title
- Reproductive & Developmental biology
- Volume
- 35
- Number
- 1
- Start Page
- 47
- End Page
- 54
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/35040
- ISSN
- 1738-2432
- Abstract
- Endocrine disruptors bind to hormone receptors on sperm membrane, therefore spermatozoa are potentially a useful model for examining estrogenic activities of endocrine disruptors. The objective of this study was to compare the effects of two xenoestrogenic compounds [genistein (Gen) and 4-tert-octylphenol (OP)] to those of two steroids [estrogen (E2) and progesterone (P4)] on boar sperm % motility and motion kinematics of in vitro. Porcine spermatozoa were incubated with various concentrations (0.001~100 μM) of each chemical for 15 or 30 min, and then assessed % motility and sperm motion kinematics using computer assisted sperm analyzer (CASA). Each chemical decreased sperm % motility, and OP decreased VSL and VAP compared with untreated control(p<0.05). E2 stimulated the motion kinematic changes except VCL. Moreover, Gen had effects on VCL and VAP alterations after 30 min incubation. In summary, since all chemicals studied effectively altered sperm % motility and motion kinematics, it was concluded that porcine spermatozoa could be a useful model for in vitro screening of potential endocrine disruptors.
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