식방풍의 성분분리 및 생리활성Biolosical Activities of Isolated Compounds from Peucedani Radix
- Authors
- 김도훈; 한지수; 김기은; 김진효; 김성건; 김호경; 오오진; 황완균
- Issue Date
- 2009
- Publisher
- 대한약학회
- Keywords
- Peucedani Radix; antioxidative effect; Peucedanum japonicum
- Citation
- 약 학 회 지, v.53, no.3, pp 130 - 137
- Pages
- 8
- Journal Title
- 약 학 회 지
- Volume
- 53
- Number
- 3
- Start Page
- 130
- End Page
- 137
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/36297
- ISSN
- 0377-9556
- Abstract
- In this study, isolation of antioxidative compounds was performed for development of anti-oxidizing agent.
CHCl3, H2O, 30%, 60% MeOH, MeOH fractions were examined antioxidative activity by DPPH, test of inhibition on NO production. It was revealed that 30%, 60% MeOH and CHCl3 fractions had significant antioxidative activity. In 30% MeOH and 60% MeOH, CHCl3 fraction, six compounds were isolated and elucidated as adenosine(Ⅰ), guanosine(Ⅱ), peucedanol 7-
O-β-D-apiofuranosyl(1→6)-β-glucopyranoside(Ⅲ), peucedanol 7-O-β-D-glucopyranoside(Ⅳ), peucedanol(Ⅴ) and scopoletin(Ⅵ) by physicochemical data and spectroscopic methods. (Negative FAB-MS, 1H-NMR, 13C-NMR). The results from antioxidative activity screening for the each compound showed that compound Ⅵ was relatively superior antioxidant ability. In anti-inflammatory activation assay, compound Ⅲ, Ⅳ, Ⅵ had concentration-dependent-activity and compound Ⅳ had superior anti-inflammatory ability. These results suggest that Peucedani Radix might be developed as a potent anti-oxidative, antiinflammatory agents and ingredients for related functional foods.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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