Glutathione peroxidase-1 gene rescues cocaine-induced conditioned place preference in mice by inhibiting σ-1 receptor expression
- Authors
- Pham, D.T.; Chung, Y.H.; Mai, H.N.; Sharma, N.; Yun, J.; Kim, H.J.; Cheong, J.H.; Jeong, J.H.; Kim, D.-J.; Shin, E.-J.; Kim, H.-C.
- Issue Date
- Sep-2019
- Publisher
- Blackwell Publishing
- Keywords
- cocaine; conditioned place preference; glutathione peroxidase-1 gene; σ-1 receptor
- Citation
- Clinical and Experimental Pharmacology and Physiology, v.46, no.9, pp 791 - 797
- Pages
- 7
- Journal Title
- Clinical and Experimental Pharmacology and Physiology
- Volume
- 46
- Number
- 9
- Start Page
- 791
- End Page
- 797
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/36467
- DOI
- 10.1111/1440-1681.13140
- ISSN
- 0305-1870
1440-1681
- Abstract
- The aim of this study was to investigate whether the glutathione peroxidase-1 gene (GPx-1) affects cocaine-induced conditioned place preference (CPP) using a mouse model. Cocaine-induced CPP was accompanied by an increase in the level of σ-1 receptor in the nucleus accumbens (NAc). This phenomenon was more pronounced in the GPx-1 gene knockout (GPx-1 KO) than in wild type (WT) mice. In contrast, the CPP and expression of σ-1 receptor were much less pronounced in GPx-1-overexpressing transgenic (GPx-1 TG) mice than non-transgenic (non-TG) mice. Treatment of the mice with BD1047, a σ-1 receptor antagonist, significantly attenuated both cocaine-induced CPP and c-Fos-immunoreactivity (c-Fos-IR) in WT and GPx-1 KO mice, although the effects were more evident in the latter group. Despite the protective effects of BD1047 on cocaine-induced CPP and c-Fos in non-TG mice, there were no additional protective effects in cocaine-treated GPx-1 TG mice, indicating that the σ-1 receptor is a critical target for GPx-1-mediated psychoprotective activity. Overall, our results suggest that GPx-1 attenuates cocaine-induced CPP via inhibition of σ-1 receptor expression. © 2019 John Wiley & Sons Australia, Ltd
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