화학물질 독성고속대량스크리닝 프로그램 ToxCastTM 분석ToxCastTM Program for High Throughput Screening ofEnvironmentalChemical Toxicity, a Review
- Authors
- 정재성; 임창원; 정다운; 최진희
- Issue Date
- Jun-2019
- Publisher
- 한국환경분석학회
- Keywords
- ToxCast; High Throughput Screening; Chemical toxicity; Data analysis; Regulatory science
- Citation
- 한국환경분석학회지, v.22, no.2, pp 77 - 83
- Pages
- 7
- Journal Title
- 한국환경분석학회지
- Volume
- 22
- Number
- 2
- Start Page
- 77
- End Page
- 83
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/36564
- ISSN
- 1226-9700
- Abstract
- As the number of new chemicals increases, traditional animal testinghas limitations in evaluating the toxicity of chemicals. In Europe and the United States, the use of non-animal alternative toxicity test methods for chemical regulation is encouraged and related research is actively carried out. In the United States, the ToxCast program is in progress using high-throughput screening (HTS) techniques. The program produced HTS in vitrotest results for 1200 assays and 9000 chemicals to develop chemical toxicity prediction models and set the priorities for toxicity assessment. In this review, we explored the outline of ToxCast, the types of assays used, and the progress of each phase. We also explored how to analyze the numerous toxicity data generated through the ToxCast program, including pre-processing, dose-response model fit, conclusion and categorization. Finally, implications for domestic utilization ofthe ToxCast database are derived.
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