A randomized, patient/evaluator-blinded, split-face study to compare the efficacy and safety of polycaprolactone and polynucleotide fillers in the correction of crow's feet: The latest biostimulatory dermal filler for crow's feet
- Authors
- Jeong, G.J.; Ahn, G.R.; Park, S.J.; Hong, J.Y.; Kim, B.J.
- Issue Date
- Jul-2020
- Publisher
- Blackwell Publishing Ltd
- Keywords
- biostimulatory; crow's feet; dermal filler; polycaprolactone; polynucleotide
- Citation
- Journal of Cosmetic Dermatology, v.19, no.7, pp 1593 - 1599
- Pages
- 7
- Journal Title
- Journal of Cosmetic Dermatology
- Volume
- 19
- Number
- 7
- Start Page
- 1593
- End Page
- 1599
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/37873
- DOI
- 10.1111/jocd.13199
- ISSN
- 1473-2130
1473-2165
- Abstract
- Background: No data on the clinical results and safety profiles of the polycaprolactone (PCL) -based dermal filler for crow's feet correction have been published. Aims: This study was designed to compare the efficacy and safety of a novel PCL-based dermal filler, DLMR01, with that of RJR, a purified polynucleotide dermal filler. Patients/Methods: A total of 30 subjects with symmetric crow's feet of 2-4 points on the Crow's Feet Grading Scale (CFGS) were enrolled in this randomized, patient/evaluator-blinded, split-face study. Each subject was randomized to receive injections of DLMR01 or RJR in their right or left crow's feet. At 4 and 12 weeks, all participants were evaluated via CFGS, Global Aesthetic Improvement Scale (GAIS), and PRIMOS software system. Results: No significant difference in CFGS, GAIS, and Ra value was detected between DLMR01 side and RJR at 12 weeks (improvement rate in CFGS from baseline at week 12—DLMR01: 48.28% [14/29], RJR: 41.38% [12/29]). Conclusion: The novel PCL-based dermal filler DLMR01 shows suitable efficacy and safety, widening the selection possibilities for clinicians and patients in the treatment crow's feet. © 2019 Wiley Periodicals, Inc.
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