Integration of Optical Applicator With Balloon Catheter for Photothermal Treatment of Biliary Stricture
- Authors
- Bak, Jinoh; Hwang, Jieun; Park, Suhyun; Kang, Hyun Wook
- Issue Date
- Oct-2017
- Publisher
- WILEY
- Keywords
- balloon catheter; bile duct; optical diffuser; photothermal treatment; tissue stricture
- Citation
- LASERS IN SURGERY AND MEDICINE, v.49, no.8, pp 781 - 786
- Pages
- 6
- Journal Title
- LASERS IN SURGERY AND MEDICINE
- Volume
- 49
- Number
- 8
- Start Page
- 781
- End Page
- 786
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3819
- DOI
- 10.1002/lsm.22688
- ISSN
- 0196-8092
1096-9101
- Abstract
- Background and Objective: Bile duct stricture is an uncommon disease in gastroenterology resulting from postoperative trauma. In spite of non-surgical treatments, clinical outcomes for the biliary strictures still encounter high restenosis and stent migration. The objective of the current study was to investigate the feasible application of a balloon catheter-integrated diffing applicator to thermally treat the bile duct stricture. Materials and Methods: 400-mm optical fibers were micro-machined and then integrated with an inflatable balloon catheter. The fabricated applicator was tested on porcine bile ducts with 20-W 980 nm laser light for 60 s, and a thermal camera was used to measure thermal response of the tissue. Due to mechanical pressure, the inflated balloon was able to expand the tissue lumen up to 6 mm in diameter. Results: Compared to control, the inner area of the treated tissue was increased by four fold (i.e., 2.74 +/- 0.05 mm2 for treated vs. 0.73 +/- 0.14 mm2 for control) during the balloon catheter-assisted laser irradiation. The laser-induced tissue temperature reached up to 80.1 +/- 6.4 degrees C (thermal gradient = 1.2 degrees C/s). A thin layer of coagulation necrosis (0.5 +/- 0.1 mm) consistently formed around the lumen. Conclusion: The proposed balloon catheter-integrated diffusing applicator can be a feasible minimally invasive device to photothermally treat the obstructive bile ducts.
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Collections - College of ICT Engineering > School of Electrical and Electronics Engineering > 1. Journal Articles
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