Anti-amyloidogenic effects of Perilla frutescens var. acuta on beta-amyloid aggregation and disaggregation
- Authors
- Kim, Da-Jeong; Kim, Min-Suk; Kim, Sunggun; Hwang, Kwang-Woo; Park, So-Young
- Issue Date
- Oct-2017
- Publisher
- WILEY
- Keywords
- aggregation; Alzheimer's disease; beta-amyloid; disaggregation; Perilla frutescens var; acuta; polyphenols
- Citation
- JOURNAL OF FOOD BIOCHEMISTRY, v.41, no.5
- Journal Title
- JOURNAL OF FOOD BIOCHEMISTRY
- Volume
- 41
- Number
- 5
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3847
- DOI
- 10.1111/jfbc.12393
- ISSN
- 0145-8884
1745-4514
- Abstract
- Beta-amyloid (A beta) aggregates are a major cause of Alzheimer's disease (AD), and the inhibition of A beta aggregation is a good therapeutic target against AD. Thus, the effects of Perilla extract (4-100 mu g/mL) on the aggregation of A beta (20 mu M) monomers and disaggregation of pre-aggregated A beta aggregates were determined. The Perilla methanol extract and its hexane fraction significantly reduced A beta aggregation determined by a Theoflavin T fluorescence assay (IC50=24.5 and 19.8 mu g/mL, respectively) and confirmed by Western blot analysis with native gels. The inhibition of A beta aggregation by hexane fraction of Perilla extract (20 and 100 mu g/mL) rescued the PC12 cells from A aggregate-induced toxicity to the levels of DMSO-treated control groups. Furthermore, hexane fraction efficiently disaggregated the preformed A beta aggregates (IC50=10.2 mu g/mL). Perilla frutescens var. acuta leaves exhibited anti-amyloidogenic effects against A beta aggregation and disaggregation.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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