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Osteogenesis and new bone formation of alendronate-immobilized porous PLGA microspheres in a rat calvarial defect model
- Authors
- Lee, Jae Yong; Kim, Sung Eun; Yun, Young-Pil; Choi, Sung-Wook; Jeon, Daniel I.; Kim, Hak-Jun; Park, Kyeongsoon; Song, Hae-Ryong
- Issue Date
- Aug-2017
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Alendronate (Aln); Porous PLGA microspheres (PMSs); Rabbit adipose-derived stem cells (rADSCs); Calvarial defect model; Bone regeneration
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.52, pp 277 - 286
- Pages
- 10
- Journal Title
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Volume
- 52
- Start Page
- 277
- End Page
- 286
- ISSN
- 1226-086X
1876-794X
- Abstract
- In this study, we evaluated in vitro osteogenic differentiation and in vivo new bone formation using the alendronate-releasing porous PLGA microsphere (Aln/PMS) system in rats with a critical-sized calvarial defect. Aln/PMS system significantly enhanced in vitro osteogenic differentiation and maturation, showing significantly enhanced ALP activity, calcium deposition and the expression of osteocalcin and osteopontin, relative to PMS alone. Also, micro-CT analyses and histology results suggested that Aln/PMS system increased mineralization and bone matrix formation compared to PMS alone. This study demonstrated that the local delivery of Aln, a potent-osteoinductive factor, significantly enhances rabbit adipose-derived stem cells osteogenesis and bone regeneration. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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