The impact of Epstein-Barr virus status on clinical outcome in diffuse large B-cell lymphoma
- Authors
- Park, Sarah; Lee, Jeeyun; Ko, Young Hyeh; Han, Arum; Jun, Hyun Jung; Lee, Sang Chul; Hwang, In Gyu; Park, Yeon Hee; Ahn, Jin Seok; Jung, Chul Won; Kim, Kihyun; Ahn, Yong Chan; Kang, Won Ki; Park, Keunchil; Kim, Won Seog
- Issue Date
- Aug-2007
- Publisher
- AMER SOC HEMATOLOGY
- Citation
- BLOOD, v.110, no.3, pp 972 - 978
- Pages
- 7
- Journal Title
- BLOOD
- Volume
- 110
- Number
- 3
- Start Page
- 972
- End Page
- 978
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/41334
- DOI
- 10.1182/blood-2007-01-067769
- ISSN
- 0006-4971
1528-0020
- Abstract
- To define prognostic impact of Epstein-Barr virus (EBV) infection in diffuse large B-cell lymphoma (DLBCL), we investigated EBV status in patients with DLBCL. In all, 380 slides from paraffin-embedded tissue were available for analysis by EBV-encoded RNA-1 (EBER) in situ hybridization, and 34 cases (9.0%) were identified as EBER-positive. EBER positivity was significantly associated with age greater than 60 years (P = .005), more advanced stage (P <= .001), more than one extranodal involvement (P = .009), higher International Prognostic Index (IPI) risk group (P = .015), presence of B symptom (P = .004), and poorer outcome to initial treatment (P = .006). The EBER+ patients with DLBCL demonstrated substantially poorer overall survival (EBER+ vs EBER(-)35.8 months [95% confidence interval (0), 0-114.1 months] vs not reached, P = .026) and progression-free survival (EBER+ vs EBER- 12.8 months [95% CI, 0-31.8 months] vs 35.8 months [95% CI, 0-114.1 months], respectively (P=.018). In nongerminal center B-cell-like subtype, EBER in situ hybridization positivity retained its statistical significance at the multivariate level (P = .045). Nongerminal center B-cell-like patients with DLBCL with EBER positivity showed substantially poorer overall survival with 2.9-fold (95% CI, 1.1-8.1) risk for death. Taken together, DLBCL patients with EBER in situ hybridization(+) pursued more rapidly deteriorating clinical course with poorer treatment response, survival, and progression-free survival.
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