Nonclassical Kinetics of Clonal yet Heterogeneous Enzymes
- Authors
- Park, Seong Jun; Song, Sanggeun; Jeong, In-Chun; Koh, Hye Ran; Kim, Ji-Hyun; Sung, Jaeyoung
- Issue Date
- Jul-2017
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF PHYSICAL CHEMISTRY LETTERS, v.8, no.13, pp 3152 - 3158
- Pages
- 7
- Journal Title
- JOURNAL OF PHYSICAL CHEMISTRY LETTERS
- Volume
- 8
- Number
- 13
- Start Page
- 3152
- End Page
- 3158
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4224
- DOI
- 10.1021/acs.jpclett.7b01218
- ISSN
- 1948-7185
- Abstract
- Enzyme-to-enzyme variation in the catalytic rate is ubiquitous among single enzymes created from the same genetic information, which persists over the lifetimes of living cells. Despite advances in single-enzyme technologies, the lack of an enzyme reaction model accounting for the heterogeneous activity of single enzymes has hindered a quantitative understanding of the nonclassical stochastic outcome of single enzyme systems. Here we present a new statistical kinetics and exactly solvable models for clonal yet heterogeneous enzymes with possibly nonergodic state dynamics and state-dependent reactivity, which enable a quantitative understanding of modern single-enzyme experimental results for the mean and fluctuation in the number of product molecules created by single enzymes. We also propose a new experimental measure of the heterogeneity and nonergodicity for a system of enzymes.
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Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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