Roles of Budding Yeast Hrr25 in Recombination and Sporulationopen access
- Authors
- Lee, Min-Su; Joo, Jeong Hwan; Kim, Keunpil
- Issue Date
- Jun-2017
- Publisher
- KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
- Keywords
- Homologous recombination; Hrr25; Meiosis
- Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.27, no.6, pp 1198 - 1203
- Pages
- 6
- Journal Title
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- Volume
- 27
- Number
- 6
- Start Page
- 1198
- End Page
- 1203
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4403
- DOI
- 10.4014/jmb.1701.01016
- ISSN
- 1017-7825
1738-8872
- Abstract
- Hrr25, a casein kinase 1 delta/epsilon homolog in budding yeast, is essential to set up mono-orientation of sister kinetochores during meiosis. Hrr25 kinase activity coordinates sister chromatid cohesion via cohesin phosphorylation. Here, we investigated the prophase role of Hrr25 using the auxin-inducible degron system and by ectopic expression of Hrr25 during yeast meiosis. Hrr25 mediates nuclear division in meiosis I but does not affect DNA replication. We also found that initiation of meiotic double-strand breaks as well as joint molecule formation were normal in HRR25-deficient cells. Thus, Hrr25 is essential for termination of meiotic division but not homologous recombination.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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