Circulating Tumor Cell Counts in Patients With Localized Prostate Cancer Including Those Under Active Surveillance
- Authors
- Choi, Se Young; Lim, Bumjin; Kyung, Yoon Soo; Kim, Yunlim; Kim, Bong Min; Jeon, Byung Hee; Park, Jae Chan; Sohn, Young Woong; Lee, Jae Hyuk; Uh, Ji-Hyun; Jang, Seongsoo; Kim, Choung-Soo
- Issue Date
- Sep-2019
- Publisher
- INT INST ANTICANCER RESEARCH
- Keywords
- Prostate biopsy; biomarker; EpCAM; PSMA; prostatectomy
- Citation
- IN VIVO, v.33, no.5, pp 1615 - 1620
- Pages
- 6
- Journal Title
- IN VIVO
- Volume
- 33
- Number
- 5
- Start Page
- 1615
- End Page
- 1620
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/44704
- DOI
- 10.21873/invivo.11645
- ISSN
- 0258-851X
1791-7549
- Abstract
- Aim: To evaluate the clinical efficacy of a circulating tumor cell (CTC) test by comparison between healthy volunteers and patients with localized prostate cancer including those under active surveillance. Materials and Methods: CTC counts in peripheral blood were compared between patients with prostate cancer (n=45) and healthy volunteers (n=17). CTCs were identified based on the expression of epithelial cell adhesion molecule (EpCAM) and counted using a SMART BIOPSY (TM) SYSTEM. Results: The number of EpCAM+ cells was significantly higher in patients with cancer than in healthy volunteers. Among the low-risk patients (n=9), two had up-staging and six had up-grading. Among those up-staged, there was one case which was EpCAM(+). Among those cases up-graded, three were EpCAM(+). In those with stage T2 tumors, the presence of Gleason pattern 5 was positively correlated with EpCAM positivity (rho=0.59, p<0.001). Conclusion: CTC counts in localized prostate cancer were associated with Gleason pattern 5. Active treatment should be considered for patients with low-risk disease during active surveillance who are found to have EpCAM+ CTCs because of a risk of up-staging and upgrading.
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