Prognostic Value of Biochemical Response Models for Primary Biliary Cholangitis and the Additional Role of the Neutrophil-to-Lymphocyte Ratio
- Authors
- Yoo, Jeong-Ju; Cho, Eun Ju; Lee, Bora; Kim, Sang Gyune; Kim, Young Seok; Lee, Yun Bin; Lee, Jeong-Hoon; Yu, Su Jong; Kim, Yoon Jun; Yoon, Jung-Hwan
- Issue Date
- Nov-2018
- Publisher
- EDITORIAL OFFICE GUT & LIVER
- Keywords
- Liver cirrhosis; biliary; Prognosis; Neutrophil-to-lymphocyte ratio
- Citation
- GUT AND LIVER, v.12, no.6, pp 714 - +
- Journal Title
- GUT AND LIVER
- Volume
- 12
- Number
- 6
- Start Page
- 714
- End Page
- +
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45091
- DOI
- 10.5009/gnl18271
- ISSN
- 1976-2283
2005-1212
- Abstract
- Background/Aims: Recently reported prognostic models for primary biliary cholangitis (PBC) have been shown to be effective in Western populations but have not been well-validated in Asian patients. This study aimed to compare the performance of prognostic models in Korean patents and to investigate whether inflammation-based scores can further help in prognosis prediction. Methods: This study included 271 consecutive patients diagnosed with PBC in Korea. The following prognostic models were evaluated: the Barcelona model, the Paris-I/II model, the Rotterdam criteria, the GLOBE score and the UK-PBC score. The neutrophil-to-lymphocyte ratio (NLR) was analyzed with reference to its association with prognosis. Results: For predicting liver transplant or death at the 5-year and 10-year follow-up examinations, the UK-PBC score (areas under the receiver operating characteristic curve [AUCs], 0.88 and 0.82) and GLOBE score (AUCs, 0.85 and 0.83) were sigpificantly more accurate in predicting prognosis than the other scoring systems (all p<0.05). There was no significant difference between the performance of the UK-PBC and GLOBE scores. In addition to the prognostic models, a high NLR (>2.46) at baseline was an independent predictor of reduced transplant-free survival in the multivariate analysis (adjusted hazard ratio, 3.74; p<0.01). When the NLR was applied to the prognostic models, it significantly differentiated the prognosis of patients. Conclusions: The UK-PBC and GLOBE scores showed good prognostic performance in Korean patients with PBC. In addition, a higt NLR was associated with a poorer prognosis. Including the NLR in prognostic models may further help to stratify patients with PBC.
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Collections - College of Business & Economics > Department of Applied Statistics > 1. Journal Articles
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