Hepatoprotective and Antioxidative Activities of Cornus officinalis against Acetaminophen-Induced Hepatotoxicity in Mice
- Authors
- Lee, Nam-Hun; Seo, Chang-Seob; Lee, Ho-Young; Jung, Da-Young; Lee, Jun-Kyung; Lee, Jin-Ah; Song, Kye Yong; Shin, Hyeun-Kyoo; Lee, Mee-Young; Seo, Young Bae; Kim, Hokyoung; Ha, Hyekyung
- Issue Date
- 2012
- Publisher
- HINDAWI PUBLISHING CORPORATION
- Citation
- EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.2012
- Journal Title
- EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
- Volume
- 2012
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/46234
- DOI
- 10.1155/2012/804924
- ISSN
- 1741-427X
1741-4288
- Abstract
- The fruit of Cornus officinalis Sieb. et Zucc. is commonly prescribed in Asian countries as a tonic formula. In this study, the hepatoprotective effect of ethanolic extracts of the fruit of C. officinalis (ECO) was investigated in a mouse model of acetaminophen- (APAP-) induced liver injury. Pretreatment of mice with ECO (100, 250, and 500 mg/kg for 7 days) significantly prevented the APAP (200 mg/kg) induced hepatic damage as indicated by the serum marker enzymes (AST, ALT, and LDH). Parallel to these changes, ECO treatment also prevented APAP-induced oxidative stress in the mice liver by inhibiting lipid peroxidation (MDA) and restoring the levels of antioxidant enzymes (SOD, CAT, and HO-1) and glutathione. Liver injury and collagen accumulation were assessed using histological studies by hematoxylin and eosin staining. Our results indicate that ECO can prevent hepatic injuries associated with APAP-induced hepatotoxicity by preventing or alleviating oxidative stress.
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