The effect of genistein on melanin synthesis and in vivo whiteningThe Effect of Genistein on Melanin Synthesis and In vivo Whitening.
- Authors
- Yang, E.-S.; Hwang, J.-S.; Choi, H.-C.; Hong, R.-H.; Kang, S.-M.
- Issue Date
- Mar-2008
- Publisher
- 한국미생물·생명공학회
- Keywords
- α-glucosidase; Genistein; Melanin; Tyrosinase; Whitening
- Citation
- Korean Journal of Microbiology and Biotechnology, v.36, no.1, pp 72 - 81
- Pages
- 10
- Journal Title
- Korean Journal of Microbiology and Biotechnology
- Volume
- 36
- Number
- 1
- Start Page
- 72
- End Page
- 81
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/46965
- ISSN
- 1598-642X
2234-1305
- Abstract
- The effect of genistein on melanin synthesis was studied using in vitro and in vivo model. Genistein inhibited melanin synthesis in cultured melan-a cells dose dependently. Tyrosinase activity was decreased by genistein treatment in melan-a cells, but genistein did not inhibit tyrosinase directly. Genistein did not affect the expression of tyrosinase in melan-a cells. Genistein inhibited the activity of α-glucosidase in vitro and the glycosylation of tyrosinase in melan-a cells. The resulting unsaturated glycosylation of tyrosinase makes it unstable and disturb correct transportation. To further clarify the effect of genistein on the melanogenesis, we established UVB-induced hyperpigmentation on the shaved backs of brown guinea pigs. The animals were exposed to UVB radiation once a week for three consecutive weeks. Genistein (1 and 2%) or vehicle alone as a control were then topically applied to the hyperpigmented areas daily. Genistein showed significant lightening effect on the UVB-induced hyperpigmentation in five weeks. Depigmenting effect was prominent in 2% genistein treatment with Fontana-Masson staining. In conclusion, genistein may be a useful agent for skin whitening.
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