Degradation of immunoglobulins, protease inhibitors and interleukin-1 by a secretory proteinase of Acanthamoeba castellanii.Degradation of immunoglobulins, protease inhibitors and interleukin-l by a secretory proteinase of Acanthamoeba castellanii
- Authors
- Na, B.K.; Cho, J.H.; Song, C.Y.; Kim, T.S.
- Issue Date
- Jun-2002
- Publisher
- 대한기생충학ㆍ열대의학회
- Citation
- The Korean journal of parasitology, v.40, no.2, pp 93 - 99
- Pages
- 7
- Journal Title
- The Korean journal of parasitology
- Volume
- 40
- Number
- 2
- Start Page
- 93
- End Page
- 99
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47212
- DOI
- 10.3347/kjp.2002.40.2.93
- ISSN
- 0023-4001
1738-0006
- Abstract
- The effect of a secretory proteinase from the pathogenic amoebae Acanthamoeba castellanii on host's defense-oriented or regulatory proteins such as immunoglobulins, interleukin-1, and protease inhibitors was investigated. The enzyme was found to degrade secretory immunoglobulin A (sIgA), IgG, and IgM. It also degraded interleukin-1 alpha (IL-1 alpha) and IL-1 beta. Its activity was not inhibited by endogenous protease inhibitors, such as alpha 2-macroglobulin, alpha 1-trypsin inhibitor, and alpha 2-antiplasmin. Furthermore, the enzyme rapidly degraded those endogenous protease inhibitors as well. The degradation of host's defense-oriented or regulatory proteins by the Acanthamoeba proteinase suggested that the enzyme might be an important virulence factor in the pathogenesis of Acanthamoeba infection.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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