Dehydroepiandrosterone-dependent induction of peroxisomal proliferation can be reduced by aspartyl esterification without attenuation of inhibitory bone loss in ovariectomy animal model
- Authors
- Kwak, CS; Kang, CM; Kang, HS; Song, KY; Lee, MS; Seong, SC; Park, SC
- Issue Date
- Oct-2000
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- dehydroepiandrosterone; aspartic acid; osteoporosis; peroxisomal proliferation; ovariectomy
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.15, no.5, pp 533 - 541
- Pages
- 9
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 15
- Number
- 5
- Start Page
- 533
- End Page
- 541
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47345
- DOI
- 10.3346/jkms.2000.15.5.533
- ISSN
- 1011-8934
1598-6357
- Abstract
- The purpose of this study was to determine whether esterification of dehydroepiandrosterone with aspartate (DHEA-aspartate) could reduce peroxisomal proliferation induced by DHEA itself, without loss of antiosteoporotic activity. Female Sprague-Dawley rats were ovariectomized, then DHEA or DHEA-aspartate was administered intraperitoneally at 0.34 mmol/kg BW 3 times a week for 8 weeks. DHEA-aspartate treatment in ovariectomized rats significantly increased trabeculae area in tibia as much as DHEA treatment. Urinary Ca excretion was not significantly increased by DHEA or DHEA-aspartate treatment in ovariectomized rats, while it was significantly increased by ovariectomy. Osteocalcin concentration and alkaline phosphatase activity in serum and cross linked N-telopeptide type 1 collagen level in urine were not significantly different between DHEA-aspartate and DHEA treated groups. DHEA-aspartate treatment significantly reduced liver weight and hepatic palmitoyl-coa oxidase activity compared to DHEA treatment. DHEA-aspartate treatment maintained a nearly normal morphology of peroxisomes, while DHEA treatment increased the number and size of peroxisomes in the liver. According to these results, it is concluded that DHEA-aspartate ester has an inhibitory effect on bone loss in ovariectomized rats with a marked reduction of hepatomegaly and peroxisomal proliferation compared to DHEA.
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