Intracellular delivery of recombinant proteins via gold nanoparticle-DNA aptamer composites is independent of the protein physicochemical properties and cell typeopen access
- Authors
- Yeom, Ji-Hyun; Joo, Minju; Lee, Boeun; Kim, Keun Pil; Ha, Nam-Chul; Park, Yoonkyung; Bae, Jeehyeon; Lee, Kangseok
- Issue Date
- Jan-2017
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- DNA aptamer; Gold nanoparticle; Protein delivery; Intravenous delivery
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.45, pp 5 - 10
- Pages
- 6
- Journal Title
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Volume
- 45
- Start Page
- 5
- End Page
- 10
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4901
- DOI
- 10.1016/j.jiec.2016.09.043
- ISSN
- 1226-086X
1876-794X
- Abstract
- Here, we report that the gold nanoparticle-DNA aptamer (AuNP-Apt) conjugate-based system can efficiently deliver recombinant proteins into mammalian cells in a manner independent of their size, isoelectric point, and cellular localization. Additionally, AuNP-Apt system-assisted protein delivery can be effective on primary and stem cells, indicating that its use is not limited to fast-dividing cells. We further show that the intravenously administered AuNP-Apt system can deliver proteins into rat organs. Our findings show that this system can serve as a simple, efficient, and versatile platform for the delivery of recombinant proteins into mammalian living systems. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
- Files in This Item
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- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
- College of Natural Sciences > Department of Life Science > 1. Journal Articles
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