Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Identfication of phase I and phase II metabolites of hesperetin in rat liver microsomes by liquid chromatography-electrospray ionization-tandem mass spectrometry
- Authors
- Kim, U.; Han, S.B.; Kwon, O.-S.; Yoo, H.H.
- Issue Date
- 2011
- Publisher
- Korean Society for Mass Spectrometry
- Keywords
- Hesperetin; In vitro metabolism; LC/MS; Rat liver microsomes
- Citation
- Mass Spectrometry Letters, v.2, no.1, pp 20 - 23
- Pages
- 4
- Journal Title
- Mass Spectrometry Letters
- Volume
- 2
- Number
- 1
- Start Page
- 20
- End Page
- 23
- ISSN
- 2233-4203
2093-8950
- Abstract
- The purpose of this study is to investigate the in vitro metabolism of hesperetin, a bioflavonoid. Hesperetin was incubated with rat liver microsomes in the presence of NADPH and UDP-glucuronic acid for 30 min. The reaction mixture was analyzed by liquid chromatography-ion trap mass spectrometer and the chemical structures of hesperetin metabolites were characterzed based on their MS/MS spectra. As a result, a total of five metabolites were detected in rat liver microsomes. The metabolites were identified as a demethylated metabolite (eriodictyol), two hesperetin glucuronides, and two eriodictyol glucuronides.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.