Preoperative Assessment of Pancreatic Cancer with FDG PET/MR Imaging versus FDG PET/CT Plus Contrast-enhanced Multidetector CT: A Prospective Preliminary Study
- Authors
- Joo, Ijin; Lee, Jeong Min; Lee, Dong Ho; Lee, Eun Sun; Paeng, Jin Chul; Lee, Soo Jin; Jang, Jin-Young; Kim, Sun-Whe; Ryu, Ji Kon; Lee, Kyoung-Bun
- Issue Date
- Jan-2017
- Publisher
- RADIOLOGICAL SOC NORTH AMERICA
- Citation
- RADIOLOGY, v.282, no.1, pp 149 - 159
- Pages
- 11
- Journal Title
- RADIOLOGY
- Volume
- 282
- Number
- 1
- Start Page
- 149
- End Page
- 159
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4986
- DOI
- 10.1148/radiol.2016152798
- ISSN
- 0033-8419
1527-1315
- Abstract
- Purpose: To determine the diagnostic performance of fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/magnetic resonance (MR) imaging in the preoperative assessment of pancreatic cancer in comparison with that of FDG PET/computed tomography (CT) plus contrast materialenhanced multidetector CT. Materials and Methods: This prospective study was approved by the institutional review board; written informed consent was obtained. Thirty-seven patients with 39 pancreatic tumors underwent preoperative FDG PET/MR imaging, PET/CT, and contrast-enhanced multidetector CT. The authors measured maximal and mean standardized uptake values (SUVmax and SUVmean, respectively) of pancreatic cancer at PET/MR imaging and PET/CT. Two radiologists independently reviewed the two imaging sets (set 1, PET/MR imaging; set 2, PET/CT plus multidetector CT) to determine tumor resectability according to a five-point scale, N stage (N0 or N positive), and M stage (M0 or M1). With use of clinical-surgical-pathologic findings as the standard of reference (n = 20), diagnostic performances of the two imaging sets were compared by using the McNemar test. Results: Both SUVmax and SUVmean of pancreatic tumors showed strong correlations between PET/MR imaging and PET/CT (r = 0.897 and 0.890, respectively; P < .001). The diagnostic performance of PET/MR imaging was not significantly different from that of PET/CT plus multidetector CT in the assessment of tumor resectability (area under the receiver operating characteristic curve: 0.891 vs 0.776, respectively, for reviewer 1 [P = .109] and 0.859 vs 0.797 for reviewer 2 [P = .561]), N stage (accuracy: 54% [seven of 13 patients] vs 31% [four of 13 patients]; P = .250 for both reviewers), and M stage (accuracy: 94% [16 of 17 patients] vs 88% [15 of 17 patients] for reviewer 1 [P > .999] and 94% [16 of 17 patients] vs 82% [14 of 17 patients] for reviewer 2 [P = .500]). Conclusion: FDG PET/MR imaging showed a diagnostic performance similar to that of PET/CT plus contrast-enhanced multidetector CT in the preoperative evaluation of the resectability and staging of pancreatic tumors. (C) RSNA, 2016
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