Structural feature of TRAFs, their related human diseases and therapeutic interventionStructural feature of TRAFs, their related human diseases and therapeutic intervention
- Authors
- Park, Hyun Ho
- Issue Date
- May-2021
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Innate immunity; TRAF family; TRAF domain; TRAF-associated diseases; Structure-based drug design
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.44, no.5, pp 475 - 486
- Pages
- 12
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 44
- Number
- 5
- Start Page
- 475
- End Page
- 486
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51718
- DOI
- 10.1007/s12272-021-01330-w
- ISSN
- 0253-6269
1976-3786
- Abstract
- Several studies have been conducted over the years to unravel the structural information on the receptors that bind to tumor necrosis factor receptor-associated factor (TRAF) and the driving forces for the TRAF/receptor complex. In addition, studies have also been performed to highlight the influence of TRAF malfunctioning and mutations on the development of human disease. However, a holistic study that systematically summarizes the available information and the existing clinical trends towards development of the TRAF-targeting drugs has not been conducted to date. Herein, I reviewed existing research that focused on the structural information of various receptors recognized by the different members of the TRAF family. I also reviewed studies on the different human diseases that occur due to TRAF malfunctioning or mutations as well as the clinical trials undertaken to treat TRAF-associated diseases.
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