Effect of a novel piperazine compound on cancer cellsopen accessEffect of a novel piperazine compound on cancer cells
- Authors
- Jeon, So Hyun; Shin, Cha-Gyun
- Issue Date
- Dec-2021
- Publisher
- Springer Science and Business Media B.V.
- Keywords
- Apoptosis; Human cancer cells; Piperazine derivative
- Citation
- Applied Biological Chemistry, v.64, no.1, pp 1 - 7
- Pages
- 7
- Journal Title
- Applied Biological Chemistry
- Volume
- 64
- Number
- 1
- Start Page
- 1
- End Page
- 7
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51863
- DOI
- 10.1186/s13765-021-00651-0
- ISSN
- 2468-0834
2468-0842
- Abstract
- Many drugs have been developed for anticancer chemotherapy. However, more anti-cancer drugs should be developed from potential chemicals to circumvent the disadvantages of existing drugs. Most anti-cancer chemicals induce apoptosis in cancer cells. This study tested the efficiency of a new chemical, the piperazine derivative 1-[2-(Allylthio) benzoyl]-4-(4-methoxyphenyl) piperazine (CB01), on glioblastoma (U87) and cervix cancer (HeLa) cells. CB01 was highly cytotoxic to these cells (IC50S < 50 nM) and induced the traditional apoptotic symptoms of DNA fragmentation and nuclear condensation at 40 nM. Western-blot analysis of the cell lysates revealed that the intracellular apoptotic marker proteins, such as cleaved caspase-3, cytochrome c, and Bax, were highly upregulated in the CB01-treated cells. Furthermore, increased activities of caspase-3 and -9, but not caspase-8, were observed. Therefore, these results suggest that CB01 can act as an anticancer chemotherapeutic by stimulating the intrinsic mitochondrial signaling pathway to induce cytotoxicity and apoptosis in cancer cells. © 2021, The Author(s).
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