TCR Transgenic Mice: A Valuable Tool for Studying Viral Immunopathogenesis Mechanismsopen access
- Authors
- Cho, Yong-Bin; Lee, In-Gu; Joo, Yong-Hyun; Hong, So-Hee; Seo, Young-Jin
- Issue Date
- Dec-2020
- Publisher
- MDPI
- Keywords
- TCR transgenic mice; immunopathogenesis; viral infection; T cell
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.21, no.24, pp 1 - 12
- Pages
- 12
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Volume
- 21
- Number
- 24
- Start Page
- 1
- End Page
- 12
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/51980
- DOI
- 10.3390/ijms21249690
- ISSN
- 1661-6596
1422-0067
- Abstract
- Viral infectious diseases are a significant burden on public health and the global economy, and new viral threats emerge continuously. Since CD4(+) and CD8(+) T cell responses are essential to eliminating viruses, it is important to understand the underlying mechanisms of anti-viral T cell-mediated immunopathogenesis during viral infections. Remarkable progress in transgenic (Tg) techniques has enabled scientists to more readily understand the mechanisms of viral pathogenesis. T cell receptor (TCR) Tg mice are extremely useful in studying T cell-mediated immune responses because the majority of T cells in these mice express specific TCRs for partner antigens. In this review, we discuss the important studies utilizing TCR Tg mice to unveil underlying mechanisms of T cell-mediated immunopathogenesis during viral infections.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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