Advanced PLGA hybrid scaffold with a bioactive PDRN/BMP2 nanocomplex for angiogenesis and bone regeneration using human fetal MSCs
- Authors
- Kim, Da-Seul; Lee, Jun-Kyu; Kim, Jun Hyuk; Lee, Jaemin; Kim, Dong Seon; An, Sanghyun; Park, Sung-Bin; Kim, Tae-Hyung; Rim, Jong Seop; Lee, Soonchul; Han, Dong Keun
- Issue Date
- Dec-2021
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Citation
- SCIENCE ADVANCES, v.7, no.50
- Journal Title
- SCIENCE ADVANCES
- Volume
- 7
- Number
- 50
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/52528
- DOI
- 10.1126/sciadv.abj1083
- ISSN
- 2375-2548
2375-2548
- Abstract
- Biodegradable polymers have been used with various systems for tissue engineering. Among them, poly(lactic-co-glycolic) acid (PLGA) has been widely used as a biomaterial for bone regeneration because of its great biocompatibility and biodegradability properties. However, there remain substantial cruxes that the by-products of PLGA result in an acidic environment at the implanting site, and the polymer has a weak mechanical property. In our previous study, magnesium hydroxide (MH) and bone extracellular matrix are combined with a PLGA scaffold (PME) to improve anti-inflammation and mechanical properties and osteoconductivity. In the present study, the development of a bioactive nanocomplex (NC) formed along with polydeoxyribonucleotide and bone morphogenetic protein 2 (BMP2) provides synergistic abilities in angiogenesis and bone regeneration. This PME hybrid scaffold immobilized with NC (PME/NC) achieves outstanding performance in anti-inflammation, angiogenesis, and osteogenesis. Such an advanced PME/NC scaffold suggests an integrated bone graft substitute for bone regeneration.
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Collections - College of ICT Engineering > School of Integrative Engineering > 1. Journal Articles
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