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Calcium-binding near-infrared fluorescent nanoprobe for bone tissue imaging
- Authors
- Lim, Y.G.; Kim, H.J.; Kim, J.W.; Park, Kyeongsoon
- Issue Date
- 25-Sep-2020
- Publisher
- Korean Society of Industrial Engineering Chemistry
- Keywords
- Alendronate; Bone tissue imaging; Calcium-binding nanoprobe; Copper-free click chemistry; Intracellular calcium detection
- Citation
- Journal of Industrial and Engineering Chemistry, v.89, pp 442 - 447
- Pages
- 6
- Journal Title
- Journal of Industrial and Engineering Chemistry
- Volume
- 89
- Start Page
- 442
- End Page
- 447
- ISSN
- 1226-086X
1876-794X
- Abstract
- We report a self-assembled calcium-binding nanoprobe which emits a near-infrared fluorescence (NIRF) signal. We have designed a calcium-binding NIRF nanoprobe by chemically coupling alendronate (ALN), a specific targeting ligand, and NIRF-emitting Cy5.5-labeled dibenzocyclooctyne, to the two respective ends of azide-polyethylene glycol-NHS ester. Prepared ALN-PEG-Cy5.5 forms the self-assembled nanostructures and has high affinity for calcium phosphates-containing bone minerals. In addition, ALN-PEG-Cy5.5 can be employed to visualize intracellular calcium ion levels in vitro as well as normal bone tissues in vivo. These results suggest that our calcium-binding NIRF nanoprobe has a promising potential for calcium imaging in vitro and in vivo. © 2020 The Korean Society of Industrial and Engineering Chemistry
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