Anti-Inflammatory Effects of Fermented Bark of Acanthopanax sessiliflorus and Its Isolated Compounds on Lipopolysaccharide-Treated RAW 264.7 Macrophage Cells
- Authors
- Kim, Min Ji; Wang, Hye Soo; Lee, Min Won
- Issue Date
- Jul-2020
- Publisher
- HINDAWI LTD
- Citation
- EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.2020
- Journal Title
- EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
- Volume
- 2020
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53467
- DOI
- 10.1155/2020/6749425
- ISSN
- 1741-427X
1741-4288
- Abstract
- The fermentation was carried out on the bark ofAcanthopanax sessiliflorus(AS).Acanthopanaxspecies have been used in traditional medicine as tonics, sedatives, and antispasmodics. An activity-guided isolation of the fermented bark ofA. sessiliflorus(FAS) yielded several phytochemicals: acanthoside D (1), acanthoside B (2), daucosterol (3), protocatechuic acid (4), chlorogenic acid methyl ester (5), ciwujiatone (6), syringaresinol (7), farnesol (8), 3,4-dicaffeoylquinic acid (9), and falcarindiol (10). HPLC analysis showed that content of lignan glycoside (1)was decreased and4and7were increased after fermentation. Anti-inflammatory activities on FAS showed the decrease of nitric oxide (NO) production, and inhibitory activities of iNOS and COX-2, proinflammatory cytokines (IL-6 and tumor necrosis factor-alpha), and collagenase. The aglycone, syringaresinol (7), which was increased through fermentation showed enhanced activity than1. Thus, FAS may have the potential to treat inflammatory disorders, such as arthritis.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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