Protective effects of protocatechuic acid against cognitive impairment in an amyloid beta-induced Alzheimer's disease mouse model
- Authors
- Choi, J.R.; Kim, J.H.; Lee, S.; Cho, E.J.; Kim, H.Y.
- Issue Date
- Oct-2020
- Publisher
- Elsevier Ltd
- Keywords
- Alzheimer's disease; Amyloid-beta; Neuroinflammation; Oxidative stress; Protocatechuic acid
- Citation
- Food and Chemical Toxicology, v.144
- Journal Title
- Food and Chemical Toxicology
- Volume
- 144
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53479
- DOI
- 10.1016/j.fct.2020.111571
- ISSN
- 0278-6915
1873-6351
- Abstract
- In this study, we investigated the protective effects of protocatechuic acid (PA) against cognitive impairment in an amyloid-beta (Aβ)-induced Alzheimer's disease (AD) mouse model. PA was administered orally for 14 days at 100 and 200 mg/kg/day. To examine effects on cognition, we conducted behavior tests including the T-maze test, novel object recognition, and the Morris water maze test. In addition, we measured lipid peroxidation, nitric oxide (NO) production, and inflammation-related protein expression in mice tissues. The PA-administered group showed more use of novel routes, better novel object recognition, and learning and memory ability compared to the Aβ25-35-injected mice in the behavior tests. The results indicated that the administration of higher PA protected against cognitive impairment. In addition, the PA-administered groups showed significantly decreased lipid peroxidation and NO production in the brain, kidney, and liver tissues. Furthermore, the PA-administered groups showed attenuated Aβ25-35-induced neuroinflammation by downregulating inflammatory mediators, inducible nitric oxide synthase and cyclooxygenase-2 in the brain. The results of the present study suggest that PA may be a protective agent against AD. © 2020 Elsevier Ltd
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