Strong Correlation of Renal Function with Choroidal Thickness in Patients with Type 2 Diabetes: Retrospective Cross-Sectional Study
- Authors
- Choi, Min Gyu; Kim, Jee Taek
- Issue Date
- Jul-2020
- Publisher
- MDPI
- Keywords
- diabetes complications; diabetes mellitus; diabetic retinopathy; diabetic nephropathies; choroidal thickness; optical coherence tomography
- Citation
- JOURNAL OF CLINICAL MEDICINE, v.9, no.7, pp 1 - 12
- Pages
- 12
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- Volume
- 9
- Number
- 7
- Start Page
- 1
- End Page
- 12
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53500
- DOI
- 10.3390/jcm9072171
- ISSN
- 2077-0383
2077-0383
- Abstract
- The purpose of this study was to analyze the correlation between renal function and subfoveal choroidal thickness (SFChT) in treatment-naive proliferative diabetic retinopathy (PDR) patients. This study included 85 eyes of 52 treatment-naive PDR patients who underwent kidney function testing and urinalysis and 42 eyes of 33 age-matched controls. Treatment-naive eyes with PDR were categorized into pachychoroid and leptochoroid groups based on the SFChT of the control group. Kidney function profiles were compared between pachychoroid and leptochoroid groups; the relationship between kidney function profile and SFChT was evaluated using regression analysis. Compared with the pachychoroid group, the leptochoroid group had significantly higher serum creatinine (p= 0.026), cystatin C (p= 0.004), and phosphorus (p< 0.001) levels and a lower estimated glomerular filtration rate (eGFR) (p< 0.001). Multivariate linear regression analyses showed that SFChT was positively correlated with eGFR (Cystatin C) (p= 0.007) and negatively correlated with serum phosphorus (p= 0.001). SFChT of patients with eGFR < 30 mL/min/1.73 m(2)and serum phosphorus level >= 4.0 mg/dL was less than that of patients with higher eGFR and lower serum phosphorus level. The choroidal thickness of treatment-naive PDR patients is closely affected by renal function. Kidney function test should be considered if SFChT of patients with treatment-naive PDR is reduced.
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