Antiproliferation effect of sulforaphene isolated from radish (Raphanus sativus L.) seeds on A549 cellsAntiproliferation effect of sulforaphene isolated from radish (Raphanus sativus L.) seeds on A549 cells
- Authors
- Lim, Sooyeon; Ahn, Jin-Chul; Lee, Eun Jin; Kim, Jongkee
- Issue Date
- Nov-2020
- Publisher
- SPRINGER SINGAPORE PTE LTD
- Keywords
- Anti-proliferation; Brassica vegetables; Human disease; Isothiocyanate; MTT assay
- Citation
- APPLIED BIOLOGICAL CHEMISTRY, v.63, no.1, pp 1 - 8
- Pages
- 8
- Journal Title
- APPLIED BIOLOGICAL CHEMISTRY
- Volume
- 63
- Number
- 1
- Start Page
- 1
- End Page
- 8
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53869
- DOI
- 10.1186/s13765-020-00561-7
- ISSN
- 2468-0834
2468-0842
- Abstract
- Sulforaphene (SFE), a major isothiocyanate in radish seeds, is a close chemical relative of sulforaphane (SFA) isolated from broccoli seeds and florets. The anti-proliferative mechanisms of SFA against cancer cells have been well investigated, but little is known about the potential anti-proliferative effects of SFE. In this study, we showed that SFE purified from radish seeds inhibited the growth of six cancer cell lines (A549, CHO, HeLa, Hepa1c1c7, HT-29, and LnCaP), with relative half maximal inhibitory concentration values ranging from 1.37 to 3.31 mu g/mL. Among the six cancer cell lines, SFE showed the greatest growth inhibition against A549 lung cancer cells, where it induced apoptosis by changing the levels of poly(ADP-ribose) polymerase and caspase-3, -8, and -9. Our results indicate that SFE from radish seeds may have significant anti-proliferative potency against a broad range of human cancer cells via induction of apoptosis.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Biotechnology & Natural Resource > ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/53869)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.