Quantitative ultrasound radiofrequency data analysis for the assessment of hepatic steatosis using the controlled attenuation parameter as a reference standard
- Authors
- Jeon, Sun Kyung; Joo, Ijin; Kim, So Yeon; Jang, Jong Keon; Park, Juil; Park, Hee Sun; Lee, Eun Sun; Lee, Jeong Min
- Issue Date
- Jan-2021
- Publisher
- KOREAN SOC ULTRASOUND MEDICINE
- Keywords
- Ultrasonography; Liver; Fatty liver
- Citation
- ULTRASONOGRAPHY, v.40, no.1, pp 136 - 146
- Pages
- 11
- Journal Title
- ULTRASONOGRAPHY
- Volume
- 40
- Number
- 1
- Start Page
- 136
- End Page
- 146
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/54111
- DOI
- 10.14366/usg.20042
- ISSN
- 2288-5919
2288-5943
- Abstract
- Purpose: This study was aimed to investigate the value of quantitative ultrasound (US) parameters from radiofrequency (RF) data analysis for assessing hepatic steatosis, using controlled attenuation parameter (CAP)-based steatosis grades as the reference standard. Methods: We analyzed 243 participants with both B-mode liver US with RF data acquisition and CAP measurements. On B-mode US images, hepatic steatosis was visually scored (0/1/2/3, none/mild/moderate/severe), and the hepatorenal index (HRI) was calculated. From the RF data analysis, the tissue scatter-distribution imaging parameter (TSI-p) and tissue attenuation imaging parameter (TAI-p) of the liver parenchyma were measured. US parameters were correlated with CAP-based steatosis grades (S0/1/2/3, none/mild/moderate/severe) and their diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis. Multivariate linear regression analysis was performed to identify determinants of TSI-p and TAI-p. Results: Participants were classified as having S0 (n=152), S1 (n=54), S2 (n=14), and S3 (n=23) on CAP measurements. TSI-p and TAI-p were significantly correlated with steatosis grades (rho =0.593 and rho=-0.617, P<0.001 for both). For predicting >= S1, >= S2, and S3, the areas under the ROC curves (AUCs) of TSI-p were 0.827/0.914/0.917; TAI-p, 0.844/0.914/0.909; visual scores, 0.659/0.778/0.794; and HRI, 0.629/0.751/0.759, respectively. TSI-p and TAI-p had significantly higher AUCs than did visual scores or HRI for =S1 or =S2 (P=0.003). In the multivariate analysis, the transient elastography-based fibrosis grade (P=0.034) and steatosis grade (P< 0.001) were independent determinants of TSI-p, while steatosis grade (P<0.001) was an independent determinant of TAI-p. Conclusion: TSI-p and TAI-p derived from US RF data may be useful for detecting hepatic steatosis and assessing its severity.
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