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A microfluidic culture system for analysis of neurotoxicity of oligomeric assemblies of amyloid beta proteins
- Authors
- Choi, Y.J.; Chae, S.; Kim, J.H.; Park, J.Y.; Lee, S.-H.
- Issue Date
- Nov-2012
- Publisher
- Chemical and Biological Microsystems Society
- Keywords
- Microfluidic gradient chip; Oligomeric assemblies of amyloid beta
- Citation
- Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, pp 902 - 904
- Pages
- 3
- Journal Title
- Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
- Start Page
- 902
- End Page
- 904
- ISSN
- 0000-0000
- Abstract
- In this paper, we introduce a microfluidic system to analyze the effect of oligomeric assemblies of amyloid beta on neurons quantitatively with well-organized in vivo-like microenvironment. By generating extremely slow flow rate and gradient of oligomeric assemblies of amyloid beta, our microfluidic platform simulates the regulated intramembrane proteolysis (RIP), a convergence physiological mechanism.
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Collections - College of Engineering > School of Mechanical Engineering > 1. Journal Articles
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