YES-10 Improves Stress, Tension, and Fatigue by Reducing Cortisol and IL-6 Levels
- Authors
- Noh, Y.-H.; Hong, J.; Lee, J.-W.; Kim, S.-S.; Kang, I.-J.; Whang, Wan Kyunn; Myung, Soon-Chul; Chung, M.-H.; Won, M.-H.
- Issue Date
- Feb-2022
- Publisher
- Mary Ann Liebert Inc.
- Keywords
- cortisol; depression; fatigue; stress; tension relief; YES-10
- Citation
- Journal of Medicinal Food, v.25, no.2, pp 205 - 212
- Pages
- 8
- Journal Title
- Journal of Medicinal Food
- Volume
- 25
- Number
- 2
- Start Page
- 205
- End Page
- 212
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/55350
- DOI
- 10.1089/jmf.2021.K.0129
- ISSN
- 1096-620X
1557-7600
- Abstract
- The extract of Clematis mandshurica Rupr. (CMR) inhibits the production of proinflammatory mediators from lipopolysaccharide-stimulated peritoneal macrophages and concanavalin A-stimulated splenocytes. Erigeron annuus Pers. (EAP) extract suppresses the production of reactive oxygen species (ROS) from preadipocytes. Furthermore, the mixture of the leaf extracts of CMR and EAP, YES-10®, protected against nerve injuries induced by ischemia/reperfusion, suggesting a ROS-scavenging action. These observations show the anti-inflammatory action of YES-10. Inflammatory cytokines can cause alterations in mental function, including depression, by influencing the neurotransmitter system. Thus, it was hypothesized that YES-10 could improve mental health, such as depression, anxiety, and sense of well-being. Seventy-two subjects were recruited and randomly divided into YES-10 or placebo groups (n = 36 per group). Each group was daily administered two capsules orally, containing 200 mg of YES-10 or placebo, for 4 weeks in a double-blinded manner and tested for levels of depression, anxiety, well-being, and mental fitness using the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Psychosocial Well-being Index (PWI), and Mental Fitness Scale (MFS). In addition, the levels of cortisol (a stress hormone), interleukin-6 (IL-6) (an inflammatory cytokine), and 8-hydroxydeoxyguanosine (8-OHdG; a marker of oxidative stress) in the serum were measured. The BDI, BAI, PWI, and MFS scores decreased significantly, and the serum levels of cortisol, IL-6, and 8-OHdG were lowered significantly (P < .05), suggesting that YES-10 has the ability to improve mental health by relieving stress and by decreasing inflammation and oxidative stress. Copyright © 2022 Mary Ann Liebert, Inc.
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