DHEA의 투여 시기가 Dexamethasone 치료 쥐의 체중과 TypeⅠ,Ⅱ 근육무게에 미치는 영향

Abstract

-Effect of DHEA Administration before, during and after Dexamethasone Treatment on Body Weight and Mass of TypeⅠ,Ⅱ Muscles in Rats

Purpose: This study was to determine the effect of DHEA administration before, during, and after dexamethasone treatment on body weight and TypeⅠ,Ⅱ muscle weight of rat receiving dexamethasone treatment.

Method: Wistar rats were divided into 6 groups: control(C), dexamethasone(D), DHEA administration for 3days after dexamethasone treatment for 7days(7D+3DH), dexamethasone treatment for 7days after DHEA administration for 3days(3DH+7D), DHEA administration during dexamethasone treatment for 4days after dexamethasone treatment for 3days(3D+4DDH), DHEA administration during dexamethasone treatment for 7days(7DDH). Dexamethasone was injected by subcutaneously daily at a dose of 5mg/kg. DHEA was orally administered daily at a dose of 5mg/kg for 7 days. Soleus(TypeⅠ) muscle, and both plantaris and gastro- cnemius(TypeⅡ) muscles were dissected on the 7th day of experiment. Result: Body weight of both 3DH+7D group and 3D+4DDH group increased significantly compared with that of 7D group. Body weight of 7D+3DH group decreased significantly compared with that of 7D group, 7DDH group, 3DH+7D group and 3D+4DDH group. Muscle weight of both plantaris and gastro- cnemius tended to decrease compared with that of 7D group. Muscle weight of 7DDH group, 3D+4DDH group and 3DH+7D group increased significantly compared with that of 7D+3DH group. Muscle weight of gastrocnemius of both 3DH+7D group and 3D+4DDH group increased significantly compared with that of 7D group. Conclusion: Based on these results, it can be suggested that DHEA administration before and during dexamethasone treatment can increase both body weight and mass of atrophied TypeⅡ muscle induced by dexa- methasone treatment.