스테로이드 치료 후 회복기의 규칙적인 운동이 어린 쥐의 스테로이드 유발성 위축 Type II 근육에 미치는 영향
- Authors
- 최명애; 신기수; 안경주; 최정안; 이윤경
- Issue Date
- Jun-2002
- Publisher
- 한국간호과학회
- Keywords
- Exercise; Steroid; Fast-twitch muscle fibers; Exercise; Steroid; Fast-twitch muscle fibers
- Citation
- Journal of Korean Academy of Nursing, v.32, no.4, pp 550 - 559
- Pages
- 10
- Journal Title
- Journal of Korean Academy of Nursing
- Volume
- 32
- Number
- 4
- Start Page
- 550
- End Page
- 559
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56036
- Abstract
- -Effect of Regular Exercise during Recovery Period Following Steroid Treatment on the Atrophied Type II Muscles Induced by Steroid in Young Rats
Purpose: This study was conducted to determine whether low intensity regular exercise following dexamethasone treatment could attenuate steroid-induced muscle atrophy.
Method: 36 Wistar-rats(90-110g) were divided into six groups: control group(C), dexamethasone treatment group(D), sedentary group after normal sedentary period(C+S), sedentary group after dexamethasone treatment period(D+S), exercise group after normal sedentary period(C+E), and excercise group after dexamethasone treatment period(D+E). D, D+S, and D+E groups received dexamethasone injection(5mg/Kg) for seven days whereas C, C+S, and C+E groups received normal saline injection. Both C+E and D+E groups ran on a treadmill for 60 minutes/day(20minutes/4hours) at 15m/min and a 10°grade for seven recovery days.
Result: Post-weight(body weight before muscle dissection) of D group significantly decreased by 16.03%, and that of D+E group significantly increased by 15.51% compared with pre-weight(body weight before steroid treatment). TypeⅡ muscle(plantaris and gastrocnemius) weights of D group were significantly lower than those of C group. Myofibrillar protein contents of typeⅡ muscles
of D group tended to decrease comparing with C group. In D+E groups, body weights and relative weights of typeⅡ muscles(muscle weight(㎎)/post-weight(g)) tended to increase comparing with D+S group.
Conclusion: It is suggested that steroid- induced muscle atrophy can be ameliorated through low intensity regular exercise after dexamethasone treatment.
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