Is gender still a predisposing factor in contrast-media associated adverse drug reactions? A systematic review and meta-analysis of randomized trials and observational studies
- Authors
- Lee, Heeyoung; Song, Seungyeon; Oh, Yun-Kyoung; Kang, WonKu; Kim, Eunyoung
- Issue Date
- Apr-2017
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Contrast media; Adverse drug reaction; Gender; Systematic review; Meta-analysis
- Citation
- EUROPEAN JOURNAL OF RADIOLOGY, v.89, pp 81 - 89
- Pages
- 9
- Journal Title
- EUROPEAN JOURNAL OF RADIOLOGY
- Volume
- 89
- Start Page
- 81
- End Page
- 89
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56065
- DOI
- 10.1016/j.ejrad.2017.01.015
- ISSN
- 0720-048X
1872-7727
- Abstract
- Objective: To evaluate the role of gender as a risk factor for developing contrast media-associated adverse drug reactions (CM-ADRs) by comparing the incidence of CM-ADR between male and female patients according to study design, ADR type, and computed tomography (CT) examination. Material and methods: We systematically searched three electronic databases for eligible studies. In the studies included (n = 18), we assessed effect estimates of the relative incidence of CM-ADR, analysed by experimental design, ADR type and CT examination. This was calculated by using a random effects model if clinical conditions showed heterogeneity; otherwise, a fixed effects model was used. Results: We identified 10,776 patients administered CM. According to the designs, studies were classified into randomised controlled trials (RCTs) and observational studies. Results were as follows: risk ratio (RR) = 1.07 (95% confidence interval (CI): 0.79-1.46, P = 0.66) for RCTs, and RR = 0.77 (95% CI: 0.58-1.04, P = 0.09) for observational studies. The results of analysis according to ADR type and for undergoing CT demonstrated that the incidence of CM-ADR did not differ between males and females. Conclusions: We found no significant difference in the incidence of CM-ADRs between male and female patients according to study design, ADR type, or CT examination. Future studies to determine why gender has shown different roles as a risk factor between CM-ADRs and non-CM ADRs are needed. (C) 2017 Elsevier B.V. All rights reserved.
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