Total synthesis of 2′,4′,6′-trimethoxy-3′,5′-dimethylchalcone derivativesopen access
- Authors
- Park, Rae Yeon; Lee, Hana; Park, Kwangyong
- Issue Date
- May-2022
- Publisher
- John Wiley and Sons Inc
- Keywords
- 2′,4′,6′-trimethoxy-3′,5′-dimethylchalcone; antidiabetic compounds; chalcone derivatives; dimethyl cardamonin; total synthesis
- Citation
- Bulletin of the Korean Chemical Society, v.43, no.5, pp 731 - 738
- Pages
- 8
- Journal Title
- Bulletin of the Korean Chemical Society
- Volume
- 43
- Number
- 5
- Start Page
- 731
- End Page
- 738
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56732
- DOI
- 10.1002/bkcs.12515
- ISSN
- 0253-2964
1229-5949
- Abstract
- 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC), which is isolated from plants, has recently attracted much attention due to its beneficial pharmacological effects. The preparation of twelve 2′,4′,6′-trimethoxy-3′,5′-dimethylchalcone (DMDMC) derivatives, which are dimethylated-derivatives of DMC, is reported herein for the first time. Our synthetic method allowed the efficient construction of the DMDMC derivatives from phloroglucinol in 37.8%–46.5% overall yields. This promising approach would be advantageous for the production of many different DMDMC derivatives in a short period of time. © 2022 Korean Chemical Society, Seoul & Wiley-VCH GmbH
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