누드 마우스에 이종이식된 인형 구강편평세포암에서 선택적 COX-2 억제제가 종양의 성장에 미치는 영향The Effect of Selective COX-2 Inhibitor on Tumor Growth of Xenografted Human Oral Cavity Cancer in Nude Mice
- Authors
- 이규석; 백상흠; 양훈식; 김춘길; 임도형; 문석균; 백광진; 이태진
- Issue Date
- Feb-2003
- Publisher
- 대한이비인후과학회
- Keywords
- Cyclooxygenase inhibitors; Squamous cell carcinoma; COX억제제; 편평상피세포암; 세포연사
- Citation
- 대한이비인후과학회지 두경부외과학, v.46, no.4, pp 313 - 317
- Pages
- 5
- Journal Title
- 대한이비인후과학회지 두경부외과학
- Volume
- 46
- Number
- 4
- Start Page
- 313
- End Page
- 317
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/56812
- ISSN
- 2092-5859
2092-6529
- Abstract
- Background and Objectives:Recent studies have demonstrated overexpression of cycloxygenase-2 (COX-2) in various can-cers including head and neck cancers. COX-2, an inducible enzyme which catalyzes the formation of prostaglandins from arachidonic acid, is expressed in some cancers. We investigated the anti-tumor effect of selective COX-2 inhibitor, Meloxicam, on Materials and Method:We inoculated the oral cavity cancer cell (KB cell) line subcutaneously into 30 athymic mice which were divided into 3 groups 1 wek after inoculation. One group received no treatment whereas two other groups received selective COX-2 inhibitor, Meloxicam, 10mg/kg and 40mg/kg three times wekly for 3 weks. We studied mean tumor volume, apoptotic index (TUNEL) and proliferative index (Ki 67) in the control and treated groups. Results:(p<0.01), and suppressed the xenografted tumor growth with significant diference (p<0.05) in the Meloxicam treated group. Al tumor expresed COX-2. Conclusion:This result suggested that the selective COX-2 inhibitors suppresed the growth of human oral cavity squamous carcinoma and a further study will be needed for determination of the pharmacologic pathway and eficacy of selective COX-2 inhibitor for head and neck cancers. (Korean J Otolaryngol 2003 ;46 :313-7)
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